Protein homeostasis at the plasma membrane.
نویسندگان
چکیده
The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.
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عنوان ژورنال:
- Physiology
دوره 29 4 شماره
صفحات -
تاریخ انتشار 2014